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In this study, the relationship between substance use and high-novelty seeking was tested using Cloninger et al's 240-items Temperament and Character Inventory(TCI) in 34 substance users(32 methamphetamine and 2 cocaine dependence disorders), 80 normal controls and 48 schizophrenics. Demographic characteristics and substance use-related past history were taken by semi-structured interview. Subjects were aged 18-45 and general psychopathology was screened by Symptom Checklist 90 revised. The results were as follows.
1) Among temperament subdivisions in the TCI, novelty seeking(NS) was significantly higher in the substance users(22.1±4.9) than the normal controls(18.0±5.0) and the schizophrenics(15.6±3.3). There were no significant differences in other temperament subdivisions such as harm avoidance, reward dependence and persistence, neither character subdivisions such as selt-directiveness, cooperativeness and self-transcendence.
2) A significant inverse correlation was found between NS and age both in the substance users(r=0.274) and the normal controls(r=0.468).
This study suggested that the biogenetic temperament characteristics in substance use disorder were related with their high novelty seeking, not low harm avoidance.

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UCI(KEPA) : I410-ECN-0101-2009-513-017216769