지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 1998.12
- 수록면
- 165 - 177 (13page)
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초록· 키워드
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Objectives : Recently, some case reports have shown that risperidone is effective to refractory obsessive-compulsive disorder. Possible explanations for efficacy of risperidone in refractory obsessive-compulsive disorder maybe due to that it is both serotonin and dopamine receptor antagonist. On the basis of serotonin-dopamine interaction hypothesis, a biological etiology of obsessive-compulsive disorder, the effect of risperidone was evaluated to the suppressed spontaneous alternation behaviour of animal model of obsessive-compulsive disorder in rats.
Methods : The apparatus for spontaneous alternation behaviour was a black plexiglas T-maze with distinctive black and white goal boxes. Black guillotine doors separated the start box and the goal boxes from the main body of the T-maze. Small cups were placed in the comers of both goal boxes(all arms measured 50×10㎝). 24 hours prior to experiment, rats(Spraque-Dawley) were food-deprived. The food-deprived rats were put into T-maze, in which both goal boxes were baited with small amounts of chocolate milk. Each rat was given 2 set of 7 trials during which it was placed in the start box and allowed to choose the one of the goal boxes for checked. After baseline of the number of choices of spontaneous alternation behaviour was stabilized, the pontaneous alternation disrupted by nonselective 5-HT agonist, 5-MeODMT(1.25㎎/㎏/IP). The experimental animals were stratified Into 5 groups ; fluoxetine(10㎎/㎏/IP), risperidone(0.1㎎/㎏/IP), haloperidol(0.l㎎/㎏/IP), fluoxetine(10㎎/㎏) with haloperidol(0.1㎎/㎏), and saline(0.5㏄/IP) control group. Each drugs were injected for 21 days as a chronic treatment. The protective effects were evaluated on the next day of discontinuation of the each drugs among 5 groups.
Results : 1) After 21 days of the drug treatment, the risperidone group and the fluoxetine group showed significant difference from the haloperidol group and the saline control group on the protection of the 5-MeODMT induced suppression of spontaneous alternation behaviour. 2) The fluoxetine group and fluoxetine with haloperidol group showed significant difference between before and after treatment in the protection of 5-MeODMT induced suppression of spontaneous alternation behaviour. The risperidone group also showed significant difference between before and after treatment in the protection of 5-MeODMT induced suppression of spontaneous alternation behaviour, but the protective effect of risperidone was superior to fluoxetine.
Conclusion : These findings suggest that both risperidone and fluoxetine have a favorable effect in the protection of 5-MeODMT induced suppression of spontaneous alternation behaviour. We think that risperidone can be possible alternatives to SSRIs in the treatment of refractory obsessive-compulsive disorder in clinical situation.
Methods : The apparatus for spontaneous alternation behaviour was a black plexiglas T-maze with distinctive black and white goal boxes. Black guillotine doors separated the start box and the goal boxes from the main body of the T-maze. Small cups were placed in the comers of both goal boxes(all arms measured 50×10㎝). 24 hours prior to experiment, rats(Spraque-Dawley) were food-deprived. The food-deprived rats were put into T-maze, in which both goal boxes were baited with small amounts of chocolate milk. Each rat was given 2 set of 7 trials during which it was placed in the start box and allowed to choose the one of the goal boxes for checked. After baseline of the number of choices of spontaneous alternation behaviour was stabilized, the pontaneous alternation disrupted by nonselective 5-HT agonist, 5-MeODMT(1.25㎎/㎏/IP). The experimental animals were stratified Into 5 groups ; fluoxetine(10㎎/㎏/IP), risperidone(0.1㎎/㎏/IP), haloperidol(0.l㎎/㎏/IP), fluoxetine(10㎎/㎏) with haloperidol(0.1㎎/㎏), and saline(0.5㏄/IP) control group. Each drugs were injected for 21 days as a chronic treatment. The protective effects were evaluated on the next day of discontinuation of the each drugs among 5 groups.
Results : 1) After 21 days of the drug treatment, the risperidone group and the fluoxetine group showed significant difference from the haloperidol group and the saline control group on the protection of the 5-MeODMT induced suppression of spontaneous alternation behaviour. 2) The fluoxetine group and fluoxetine with haloperidol group showed significant difference between before and after treatment in the protection of 5-MeODMT induced suppression of spontaneous alternation behaviour. The risperidone group also showed significant difference between before and after treatment in the protection of 5-MeODMT induced suppression of spontaneous alternation behaviour, but the protective effect of risperidone was superior to fluoxetine.
Conclusion : These findings suggest that both risperidone and fluoxetine have a favorable effect in the protection of 5-MeODMT induced suppression of spontaneous alternation behaviour. We think that risperidone can be possible alternatives to SSRIs in the treatment of refractory obsessive-compulsive disorder in clinical situation.
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UCI(KEPA) : I410-ECN-0101-2009-513-017205764