지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.3
- 수록면
- 9 - 13 (5page)
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초록· 키워드
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Diesel exhausted particles (DEP), a kind of fine particles with aerodynamic diameters less than 2.5 ㎛ (PM2.5), is of great concern to human health because they remain in atmosphere for long periods, invade an indoor air environment, and can be breathed most deeply into lung and reached the alveoli because of their small size (0.1~0.4 ㎛ in diameter). Epidemiological and experimental studies suggested that DEP may play an active role in the increased respiratory mortality and morbidity. In addition to their physical characteristics, the chemical components including polyaromatic hydrocarbon (PAH) are regarded as a carcinogen causing pulmonary tumors. PLD plays an important role in cell proliferation with various physiological phenomena and affects other enzymes by activating signal transduction pathway. We investigated the cytotoxic mechanism of DEP on RAW 264.7 cells focusing on the role in activation of PLD. Our results suggested DEP induced PLD activity through a specific signaling pathway involving phospholipase A₂, PLC, PKC and Ca<SUP>2+</SUP> mobilization.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULT
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
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C6세포에서 phospholipase $A_2$활성에 대한 ATP의 작용
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In Vitro DNA Damages of Diesel Exhaust Particle Extract
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UCI(KEPA) : I410-ECN-0101-2009-513-015599992