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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 1996.6
- 수록면
- 539 - 549 (11page)
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초록· 키워드
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Large bowel cancer correlates tightly to dietary factors such as dietary fiber and fat. Dietary fiber prevents the large bowel cancer in different modes of action which depend upon physicochemical and fermentable properties. Water-soluble fiber is fermented easily by intestinal microbes producing short chain fatty acids ; in contrast, water-insoluble fiber occurs effectively more rapid transit time due to greater bulk of gut content, though it is unfermentable. Not only short chain fatty acid is utilized in the proximal and distal colon as primary energy source, but also it lowers pH in the colon to normalize cellular differentiation and helps to stimulate peristaltic movement by acting as an osmotic laxative. In particular, butyric acid may also regulate gene expression and cell growth, though it is an important respiratory fuel for the colonocyte. Since dietary fiber and non-digestible oligosaccharides are the major source of butyric acid, this provides a possible link between dietary fiber and oligosaccharide and prevention of large bowel cancer. But, as with many links between dietary fiber and large bowel cancer, a direct casual association has not been established. In addition, RDA of dietary fiber which is 20~25g/day for adult Japanese, appears to be reasonable for the defecation once daily and the prevention of large bowel cancer.
목차
Abstract
EPIDEMIOLOGY OF COLON CANCER
DIETARY FACTORS AND COLON CANCER
FERMENTATION OF DIETARY FIBER AND COLON CANCER
TISSUE ENLARGEMENT BY DIETARY FIBER AND COLON CANCER
OLIGOSACCHARIDE AND COLON CANCER
RECOMMENDED DIETARY ALLOWANCE OF DIETARY FIBER
SUMMARY OF MECHANISM OF DIETARY FIBER TO PREVENT LARGE BOWEL CANCER
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2009-511-018100324