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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.9 No.1
- 발행연도
- 2004.3
- 수록면
- 71 - 78 (8page)
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초록· 키워드
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Adrenergic receptors play a major role in thermogenesis and lipolysis in brown and visceral adipose tissues, and have been implicated in the pathogenesis of obesity and metabolic disorders. The purpose of this study was to estimate the effects of β2-adrenergic receptor (β2AR) and β3-adrenergic receptor (β3AR) genotypes on hyperglycemia and obesity in the Korean population. A representative sample consisting of 530 Korean men and women were measured for height, weight, BMI, WHR, obesity index and body composition. The genotypes of β2AR polymorphism in codon 27 and β3AR polymorphism in codon 64 were analyzed by the PCR RFLP method. Serum concentrations of fasting glucose, total cholesterol, HDL cholesterol and triglyceride were determined. The frequencies of β2AR and β3AR genotype were: both wild type, 62.5%; only β2AR variant type, 12.8%; only β3AR variant type, 18.8%; and both variant type, 5.8%; the frequency of E and R alleles were 0.098 and 0.137, respectively. Among the physiological parameters, fasting glucose level was significantly higher in subjects with both variant type compared with the three other types (p＜0.05). Subjects with both variant type had 12%, 12% and 9.3% increases in serum glucose levels compared with wild type, only β2AR variant type, and only β3AR variant type, respectively. When logistic regression analysis was conducted to estimate the risk for hyperglycemia, the subjects were selected for fasting blood glucose concentrations of more than 6.105 mmol/L (110 mg/dL), and the odds ratios were 1.215 (p=0.636) for only β2AR variant type, 1.659 (p=0.089) for only β3AR variant type, and 3.078 (p=0.011) for both variant type. These results suggest that the interaction of β2AR and β3AR variant genotypes has a strong association with increased glucose levels, and might be a significant risk factor for hyperglycemia among Korean subjects.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISSCUTION
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2009-511-018079586