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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.3
- 수록면
- 46 - 53 (8page)
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The current study investigated the effect of Korean safflower (Carthamus tinctorius L.) seed powder, its water, ethanol extracts on bone metabolism during recovery from rib-fracture induced by surgical operation in rats. 10-week-old male Sprague-Dawley rats weighing about 320 g were divided into 9 groups after arrival: 10d control (AIN 76 semi-purified diet), 10d safflower seed powder (10d SS-powder), 10d safflower seed ethanol extract (10d SS-EtOH), 10d safflower seed water extract (10d SS-H2O), 20d control (AIN-76 semi-purified diet), 20d safflower seed powder (20d SS-powder), 20d safflower seed ethanol extract (20d SS-EtOH), 20d safflower seed water extract (20d SS-H2O),, 20d sham-operation (20d sham). The dietary level for all the supplements was 5% based on the raw material weight. The rats were fed the experimental diets for 10 days before the rib fracture operation, for a further 10 or 20 days after the operation. A number 9 rib was fractured surgically, a sham-operation also performed. The rats were then sacrificed on the 10th or 20th day after the operation. The body weight initially decreased after the operation in all the rib-fractured groups, then gradually recovered. The concentrations of plasma osteocalcin were higher in the control group than in all the safflower-supplemented groups 10, 20 days after the rib-fracture (p＜0.05). The bone-specific ALP (alkaline phosphatase) activity was significantly higher in the SS-EtOH group than in the other groups 20 days after the rib-fracture (p＜0.05). The level of urinary DPD (deoxypridinoline) was significantly higher in the SS-EtOH, SS-H₂O groups than in the other groups 10 days after the rib-fracture. When comparing the PTH (parathyroid hormone), calcitonin levels, the SS-H₂O group exhibited the highest PTH level among the groups 10, 20 days after the rib-fracture. Thus, it was concluded that the bone turnover during the fracture-healing period was more rapid in the rats supplemented with safflower seed powder or its fractions than in the control rats. Furthermore, the SS-H₂O fraction was identified as the most effective in stimulating bone remodeling, as bone resorption, bone formation were both significantly increased during fracture healing when compared to the control group.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2009-511-018078983