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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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We investigated the compositional changes of glycoconjugates (GCs) and expression of estrogen receptor (ER)-α, c-fos and c-jun in the vagina of normal and ovariectomized rats by histochemical and immunohistochemical methods. The mucinous transformation of the superficial layer that occurred from late diestrus to proestrus was accompanied with extensive enrichment of GCs. According to the cyclic changes of the vagina, distinct reactivity patterns such as SBA affinity in the diestrus and Con A affinity in the diestrus and estrus phase was observed. However, weak staining for GCs was detected in the atrophied vaginal epithelium of ovariectomized rats.
ER-α immunoreaction was mainly demonstrated in the basal layer of epithelium and estrus cycle-related variation in the number of ER-α immunoreaction were not pronounced. But the stromal cells showing ER-α immunoreaction were abundantly observed from diestrus to estrus phase. The most numerous c-fos immunoreactive cells were observed in the basal and intermediate layer of epithelium and stromal cells from the proestrus to estrus phase and c-jun in the basal layer of epithelium during estrus phase. The c-jun immunoreaction of stromal cells expressed only in the estrus phase. In the ovariectomized rats, a few of ER-α, c-fos and c-jun immunoreactive cells were observed in the vaginal epithelium and no immunoreaction were found in the stromal cells.
ER-α and c-fos immunoreaction fully expressed in the proestrus coincident with the cell proliferation, mucinous transformation and cornification of vaginal epithelium. These data indicate that vagina epithelium and stromal cells express multiple protein such as ER-α, c-fos and c-jun by estrogen that may function in process of cells proliferation and differentiation of vagina epithelium.
ER-α immunoreaction was mainly demonstrated in the basal layer of epithelium and estrus cycle-related variation in the number of ER-α immunoreaction were not pronounced. But the stromal cells showing ER-α immunoreaction were abundantly observed from diestrus to estrus phase. The most numerous c-fos immunoreactive cells were observed in the basal and intermediate layer of epithelium and stromal cells from the proestrus to estrus phase and c-jun in the basal layer of epithelium during estrus phase. The c-jun immunoreaction of stromal cells expressed only in the estrus phase. In the ovariectomized rats, a few of ER-α, c-fos and c-jun immunoreactive cells were observed in the vaginal epithelium and no immunoreaction were found in the stromal cells.
ER-α and c-fos immunoreaction fully expressed in the proestrus coincident with the cell proliferation, mucinous transformation and cornification of vaginal epithelium. These data indicate that vagina epithelium and stromal cells express multiple protein such as ER-α, c-fos and c-jun by estrogen that may function in process of cells proliferation and differentiation of vagina epithelium.
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UCI(KEPA) : I410-ECN-0101-2009-470-014219888