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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.12
- 수록면
- 274 - 278 (5page)
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Phthalates, suspected endocrine disruptor, are plasticizer and solvent used in industry, and some phthalates are known as potential carcinogen. Most common human exposure to this compounds may occur with contaminated food. It may migrate into food from plastic wrap or may enter food from general environmental contamination, and it has become widespread environmental pollutants, thus leading to a variety of phthalates that possibly threaten the public health. Dibutyl phthalate (DBP) may play a part of cell proliferator, which mediates changes in gene expression and the metabolism of xenobiotics. An understanding of the role of DBP in modulating gene regulation should provide insight regarding mechanisms of DBP induced xenoestrogenic impact. To elucidate the type of genes that are associated with estrogenic activity induced by DBP at the dose (10-8 M) appeared proliferating effects, the pattern of gene expression in MCF7 cells was compared between 17β-estradiol and DBP exposure in the cDNA microarray. From the results, it showed some differences of gene expression patterns between MCF7 cells treated with 17β-estradiol and DBP, and also DBP shows estrogenic potential with changes in estrogen-related gene expression levels.
목차
ABSTRACT
Introduction
Materials and methods
Results and Discussion
References
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Gene expression profile and estrogenicity of dibutyl phthalate in MCF7 cells using cDNA microarray and E-screening test
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Altered Gene Profiles using KISTCHIP-400 in MCF-7 cells after Exposure to Di(2-ethylhexyl) Phthalate (DEHP) and Dibutyl Phthalate (DBP)
환경독성보건학회 심포지엄 및 학술대회
2003 .10
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한국실험동물학회 학술발표대회 논문집
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마우스에서 bibutyl phthalate 급성 투여가 간 지질과산화와 gamma-glutamy1 transferase 활성에 미치는 효과
환경위생공학
2004 .03
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Comparative effects of dibutyl phthalate (DBP) on oxidative damages antioxidant status in the testis of hypo- and hyperthyroid rats
환경독성보건학회 심포지엄 및 학술대회
2005 .05
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Gene expression profile of Phthalates with Estrogenicity
환경독성보건학회 심포지엄 및 학술대회
2005 .05
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Toxicogenomic Analysis and Identification of Estrogen Responsive Genes of Di (n-ethylhexyl) Phthalate in MCF-7 Cells
Molecular & cellular toxicology
2005 .01
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프탈레이트의 노출 정도 및 인구학적 특성과의 관련요인
Toxicological Research
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Gene Expression Profiling Study of Phthalate Analogues, Endocrine Disrupting Chemicals, in the Environment
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2005 .11
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SD Rat에 있어서 출생 전·후에 걸친 Di(n-butyl) Phthalate 노출에 의한 발생면역독성
Toxicological Research
2002 .12
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cDNA Microarray Analysis of the Gene Expression after Ad5CMV-p16INK4a Gene Transfer in the Non-Small Cell Lung Cancer Cells
대한약학회 학술대회
2001 .01
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Phthalate 유도체의 estrogenicity에 관한 연구 ( A Study of estrogenic activities of seven phthalate esters )
환경독성보건학회 심포지엄 및 학술대회
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Gene Expression Profile and Its Interpretation in Squamous Cell Lung Cancer
Molecular & cellular toxicology
2006 .01
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cDNA microarray analysis of gene expression based on Sasang
대한동의병리학회 학술대회논문집
2003 .07
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cDNA Microarray Analysis of Gene Expression Profiles Associated with Cervical Cancer
Cancer Research and Treatment
2003 .01
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The Differential Gene Expression Profiles between Sensitive and Resistant Breast Cancer Cells to Adriamycin by cDNA Microarray
Cancer Research and Treatment
2004 .01
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Profiling of Gene Expression According to Cancer Stage in Clear Cell Type of Renal Cell Carcinoma
Molecular & cellular toxicology
2005 .01
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UCI(KEPA) : I410-ECN-0101-2009-476-013751563