지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2001.3
- 수록면
- 30 - 33 (4page)
이용수
초록· 키워드
오류제보하기
Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, SAL), a dopaminergic isoquinoline neurotoxin, has been implicated to contribute the etiology of Parkinson's disease and neuropathology of chronic alcoholism . In our previous results, SAL was reported to have the mutagenicity and clastogenicity not in bacteria but in mammalian cells, and its genotoxic potential was known to be potentiated in the presence of rat liver S-9 fraction. This may indicate that some metabolite(s) of SAL was involved in the mutagenic potentials. To investigate the SAL metabolites, the metabolism studies of SAL were conducted in vitro rat liver S-9
fraction and in vivo using rats by high performance liquid chromatography and gas chromatography/mass spectrometry. The methylated metabolite of SAL was found in urine of rats, while the same methylating form of metabolite was not produced from the in vitro metabolism system using rat liver S-9 fraction.
fraction and in vivo using rats by high performance liquid chromatography and gas chromatography/mass spectrometry. The methylated metabolite of SAL was found in urine of rats, while the same methylating form of metabolite was not produced from the in vitro metabolism system using rat liver S-9 fraction.
목차
ABSTRACT
Introduction
Materials and Methods
Results and Discussion
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
흰쥐에서 SAL5의 알코올성 지방간 형성에 미치는 영향
대한본초학회지(본초분과학회지)
2018 .01
-
알코올 의존과 파킨슨병 병태생리에서의 살소리놀(Salsolinol)
신경정신의학
2008 .01
-
In vivo rat metabolism of red ginseng extract
고려인삼학회 학술대회
2011 .04
-
The Serum or Urinary Levels of Cyclohexane Metabolites in Liver Damaged Rats
대한의생명과학회지
2006 .09
-
Metabolism of YH1885 by Rat, Dog, Monkey and Human Liver S9 Fractions
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1998 .01
-
Effect of Aging on the Xylene Metabolism in CCl₄-Induced Liver Damaged Rats
대한의생명과학회지
2001 .09
-
흰쥐 骨組織의 Na 代謝에 關한 實驗的 硏究
Annals of Surgical Treatment and Research
1965 .12
-
Identification of Metabolites of Phytosterols in Rat Feces Using GC/MS
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2000 .01
-
In vitro metabolism of a novel phosphodiesterase-5 inhibitor DA-8159 in rat liver preparations using LC/MS
대한약학회 학술대회
2002 .01
-
Identification of Propentofylline Metabolites in Rats by Gas Chromatography/Mass Spectrometry
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2000 .01
-
The effect of exercise and carbohydrate metabolism in rats
한국실험동물학회 학술발표대회 논문집
2008 .05
-
IN VITRO METABOLISM OF A NEW PROTON PUMP INHIBITOR KR60436 IN RAT AND HUMAN LIVER MICROSOMES
대한약학회 학술대회
2000 .01
-
Effects of the Acute and Subacute Administration of 1-(N-methyl) piperazinyl-3-phenyl-isoquinoline on Rat Kidney
Toxicological Research
2000 .03
-
Tentative identification of 20(S)-protopanaxadiol metabolites in human plasma and urine using ultra-performance liquid chromatography coupled with triple quadrupole time-of-flight mass spectrometry
Journal of Ginseng Research
2019 .10
-
Identification of JG-381 metabolite in rats
대한약학회 학술대회
2001 .01
-
Characterization of Deoxypodophyllotoxin Metabolism in Rat Liver Microsomes
Biomolecules & Therapeutics(구 응용약물학회지)
2008 .01
-
Metabolism study of CKD-732, a novel anti-angiogenic fumagillin derivative, with in vitro rat hepatic microsome and rat plasma, urine and bile.
대한약학회 학술대회
2001 .01
-
BASIC PROCEDURES IN THE RAT
대한외과학회 학술대회 초록집
1998 .11
-
백서(白鼠)의 중완(中脘)에 시술(施術)한 청풍등약침(靑風藤藥鍼)이 항암(抗癌) 및 면역기능(免疫機能)에 미치는 영향(影響)
대한침구의학회지
2004 .01
-
In Vitro Screening Techniques for Reactive Metabolites Detection
환경독성보건학회 심포지엄 및 학술대회
2011 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-476-013746888