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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2000.3
- 수록면
- 26 - 33 (8page)
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Genetic polymorphisms of metabolizing enzymes to chemical carcinogens have been recognized as a major important host factors in human cancers. To determine the frequencies of genotypes of CYP1A1 and GSTM1 metabolizing enzymes in healthy controls and head and neck cancer patients in Korean and to identify the relative high risk genotypes of these metabolizing enzymes to head and neck cancer, we have analyzed 133 head and neck cancer patients and corresponding healthy controls matched in age and sex using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). In analysis of CYP1A1, the Val/Val genotype of exon 7 polymorphism and m2/m2 genotype of Msp 1 polymorphism were associated with higher relative risks to head and neck cancers (Odds ratio : 2.34, 95% CI : 0.79-6.96 and 1.27, 95% CI : 0.59-2.73,
respectively). In combined genotyping of CYP1A1 and GSTM1 enzymes polymorphisms, the patients with Val/Val and GSTM1(-), and m1/m2l and GSTM1(-) combined genotypes had higher relative risks than the patients with each base genotype of combined genotypes (Odds ratio : 4.57, 95% CI : 0.51-41.25 and 1.65, 95% CI : 0.73-3.77, respectively). These results suggest the combined genotype of Val/Val and GSTM1(-) was more susceptible to head and neck cancers in Korean and genotyping of metabolizing enzymes could be useful for predicting individual genetic susceptibility and screening the high risk subpopulation to head and neck cancer in Korean.
respectively). In combined genotyping of CYP1A1 and GSTM1 enzymes polymorphisms, the patients with Val/Val and GSTM1(-), and m1/m2l and GSTM1(-) combined genotypes had higher relative risks than the patients with each base genotype of combined genotypes (Odds ratio : 4.57, 95% CI : 0.51-41.25 and 1.65, 95% CI : 0.73-3.77, respectively). These results suggest the combined genotype of Val/Val and GSTM1(-) was more susceptible to head and neck cancers in Korean and genotyping of metabolizing enzymes could be useful for predicting individual genetic susceptibility and screening the high risk subpopulation to head and neck cancer in Korean.
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UCI(KEPA) : I410-ECN-0101-2009-476-013746828