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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 1999.6
- 수록면
- 169 - 175 (7page)
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초록· 키워드
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The study was carried out to investigate the effects of water or ethanol extracts from Rhus verniciflua Stokes (RVS) on antitumor and cholesterol level in mouse. Also, to measure antioxidative activities, the extracts from RVS were estimated by deoxyribose and hypoxanthine/xanthine oxidase assay. When mice were treated with RVS extracts as described in experimental design, concentration of total plasma cholesterol (TC), low density lipoprotein (LDL), and very low density lipoprotein (VLDL) cholesterol were significantly lower (P<0.001) in the two groups treated with water or ethanol extracts respectively, compared to it in control. To test the inhibitory effect of RVS extracts on tumor growth, in vivo, mice (BALB/c) were inoculated with 0.25 ml/head CT-26 cells (1 ×106 cells/ml) subcutaneously. On day 1, 4, 8, and 16 after inoculation, the mice were injected directly into the tumor tissues with 25 ㎕ of water extract (30 mg/ ml) or 25 ㎕ of ethanol extracts (30 mg/ml) from RVS individually. On day 23, the mice were killed and the size of tumor tissues were measured as unit of centimeter through diameter. When the mice were injected with water or ethanol extracts on day 1 after inoculation of CT-26 cells, the tumor sizes were measured with 0.4 cm or 0.5 cm respectively, while the size was 1.5 cm in control, which was not treated with any RVS extracts after inoculation of CT-26 cells. In general, ethanol extracts of RVS were shown more inhibitory effect of tumor growth than that in water extracts of RVS. In deoxyribose and hypoxanthine/xanthine oxidase assay, all the RVS extracts resulted to scavenge superoxide (0-₂) as well as hydroxyl radical (OHㆍ) efficiently. Especially the antioxidative activity against hydroxyl radical was shown more specific in ethanol extract of RVS than that of water extract. In conclusion, this experiment indicated that RVS extracts can playa role as tumor growth inhibitors as well as natural antioxidant and reduced cholesterol level in mouse plasma.
목차
ABSTRACT
Ⅰ. INTRODUCTION
Ⅱ. MATERIALS AND METHODS
Ⅲ. RESULTS
Ⅳ. DISCUSSION
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2009-513-013746620