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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.6
- 수록면
- 141 - 146 (6page)
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A nonspecific immunostimulator BARODON® was tested for mutagenicity using Ames Salmonella tester strains TA98, TA100, TA102, TA1535 and TA1537 with or without metabolic activation
(S9 mix). None of the fresh species showed mutagenicity. In the reverse mutation test using Salmonella typhimurium TA98, TA100, TA102, TA1535 and TA1537 did not increase the number of revertants at all doses tested (5, 2.5 or 1.25 mg/ml). Chromosome aberration test was carried out in Chinese hamster lung (CHL) cell line. The cells were treated with BARODON® (1, 0.5 or 0.25 mg/ml), while positive control group was treated with Mitomycin C (0.1 mg/ml). The results show that there is no statistically significant difference between positive control and treatment groups. In mouse micronucleus test, there was significant increase in the ratio of micronucleated polychromatic erythrocyte (MNPCE) in the high dose group (10% BARODON®), while there is no significance between control and low (2.5% BARODON®) or middle (5% BARODON®) dose groups. Taken togather, this results suggest that below 5% BARODON® might not have mutagenic potential in vitro and vivo systems.
(S9 mix). None of the fresh species showed mutagenicity. In the reverse mutation test using Salmonella typhimurium TA98, TA100, TA102, TA1535 and TA1537 did not increase the number of revertants at all doses tested (5, 2.5 or 1.25 mg/ml). Chromosome aberration test was carried out in Chinese hamster lung (CHL) cell line. The cells were treated with BARODON® (1, 0.5 or 0.25 mg/ml), while positive control group was treated with Mitomycin C (0.1 mg/ml). The results show that there is no statistically significant difference between positive control and treatment groups. In mouse micronucleus test, there was significant increase in the ratio of micronucleated polychromatic erythrocyte (MNPCE) in the high dose group (10% BARODON®), while there is no significance between control and low (2.5% BARODON®) or middle (5% BARODON®) dose groups. Taken togather, this results suggest that below 5% BARODON® might not have mutagenic potential in vitro and vivo systems.
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UCI(KEPA) : I410-ECN-0101-2009-513-013746266