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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.9
- 수록면
- 275 - 283 (9page)
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Fungal metabolite, gliotoxin is an epipolythiodioxopiperazin (ETP) class and has various roles including immunomodulatory and apoptotic effects. This study was designed to evaluate the mechanism by which gliotoxin exerts the apoptosis on human promyelocytic leukemic HL-60 cells. Herein, we demonstrated that the gliotoxin decreased the cell viability in a time-dependent manner. Gliotoxin-induced cell death was confirmed as apoptosis characterized by chromatin condensation and ladder-pattern fragmentation of genomic DNA. Gliotoxin increased the catalytic activities of caspase-3 and caspase-9. Activation of caspase-3 was further confirmed by degradation of procaspase-3 and poly(ADP-ribose) polymerase(PARP) by gliotoxin in HL-60 cells. Furthermore, gliotoxin induced the changes of mitochondrial transmembrane potential (MTP). Antioxidants, including GSH and NAC, markedly inhibited apoptosis with consistent suppression of enzymatic activity of caspase-3, caspase-9, and MTP loss in gliotoxin-treated cells. Taken together, we suggest that gliotoxin functions as an oxidant and plays proapoptotic roles in HL-60 cells via activation of intrinsic caspase cascades as well as mitochondrial dysfunction.
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Gliotoxin에 의해 유발된 아폽토시스에 대한 Protein Kinase C (PKC) 전처리의 영향
해부·생물인류학
2000 .03
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Gliotoxin Protects Trinitrobenzene Sulfonic Acid-Induced Colonic Damage through Induction of Heme Oxygenase-1
Toxicological Research
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배양심근세포에서 gliotoxin 처리로 유도된 apoptosis 연구
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Gliotoxin-induced apoptosis is blocked by PKC preconditioning
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Protective Effect of PKC Affecting Gliotoxin-induced Cytotoxicity in Rat Smooth Muscle Cells
대한체질인류학회 학술대회 연제 초록
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Anti-Angiogenic Activities of Gliotoxin and 1ts Methylthio-Derivative, Fungal Metabolites
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2001 .01
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[지상18]The protective roles of gliotoxin on TNBS-induced colitis in mice
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Arsenic Trioxide Induces Apoptosis of HL-60 Cells via Activation of Intrinsic Caspase Protease with MitochondrialDysfunction
Cancer Research and Treatment
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[지상 29] Gliotoxin Reduces Severity of Trinitrobenzene Sulfonic Acid-Induced Colitis in Mice: Evidences for the Connection between Heme Oxygenase-1 and NF-B Pathway in vitro and in vivo
대한체질인류학회 학술대회 연제 초록
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백혈병 세포주 HL-60에서 과루실 세포고사 유도 효과
동의생리병리학회지
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Induction of the apoptosis of HL -60 leukemia cells by Scytosiphon lomentaria
한국응용약물학회 추계학술발표논문집
2003 .01
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혈액암 세포에서 부자(附子) 추출물의 Apoptosis 유도 효과
동의생리병리학회지
2005 .01
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백혈병 세포주 HL-60에서 과루실(瓜蔞實)의 세포고사 유도 효과
한국전통의학지
2006 .01
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6,8-Dihydroxy-7-methoxy-1-methyl-azafluorenone Induces Caspase-8- and -9-mediated Apoptosis in Human Cancer Cells
Asian Pacific journal of cancer prevention : APJCP
2013 .01
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Caspase-dependent apoptosis by naphthoquinone analog in HL-60 cells
대한약학회 학술대회
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Mechanism of Apoptotic Cell Death by 2,4,3',5'-Tetramethoxystilbene in Human Promyelocytic Leukemic HL-60 Cells
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2007 .01
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In vitro Cytotoxicity and Apoptotic Effect of Chloromethyl-2-dihydroxyphosphinyl-6,7-dimethoxy-1,2,3,4- tetrahydroisoquinoline on HL-60 Cells
동의생리병리학회지
2005 .01
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Establishment of a High-Throughput Screening System for Caspase-3 Inhibitors
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2000 .01
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UCI(KEPA) : I410-ECN-0101-2009-513-013456510