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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.6
- 수록면
- 183 - 190 (8page)
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The mechanism by which catechin-mediated cytotoxicity against tumor cells remains to be elusive. To elucidate the mechanical insights of anti-tumor effects, (-)epigallocatechin-gallate (EGCG) of catechin was applied to human prostate cancer DU145 cells. Cell viability was measured by crystal violet staining. Cell lysates were used to measure the catalytic activity of caspases by using fluorogenic peptide; Ac-DEVD-AMC for caspase-e protease, Z-IETD-AFC for caspase-8 protease, Ac-LEHD-AFC for caspase-9 protease as substrates. The equal amounts of protein from cell lysate was separated on SDS-PAGE and analyzed by western blotting with anti-Fas antibody, anti-FasL antibody, anti-BCL2 antibody and anti-Bax antibody. (-)EGCG induced the death of DU145 cells, which was revealed as apoptosis shown by DNA fragmentation. (-)EGCG induced the activation of caspase family systeine proteases including caspase-3, -8 and -9 proteases in DU145 cells. Also, (-)EGCG increased the expression of Fas and Fas ligand (FasL) protein in DU145 cells. The expression level of BCL2 was decreased in (-)EGCG-induced apoptosis of DU145 cells is mediated by signaling pathway involving caspase family cysteine protease, mithchondrial BCL2-family proteins and Fas/FasL.
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UCI(KEPA) : I410-ECN-0101-2009-513-013456409